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KMID : 0359920140330040187
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Korean Journal of Nephrology
2014 Volume.33 No. 4 p.187 ~ p.191
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Reanalysis of membranoproliferative glomerulonephritis patients according to the new classification: a multicenter study
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Woo Sung-Ae
Ju Hye-Young
Kwon Soon-Hyo
Lee Ji-Hye
Choi Soo-Jeong
Han Dong-Cheol
Hwang Seung-Duk
Hong Sae-Yong
Jin So-Young
Gil Hyo-Wook
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Abstract
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Background: All types of membranoproliferative glomerulonephritis (MPGN) are progressive diseases with poor prognoses. Recently, a newly proposed classification of these diseases separated them into immune complex- and complementmediated diseases. We investigated the frequency of C3 glomerulonephritis among previously diagnosed MPGN patients.
Methods: We conducted a retrospective study of patients diagnosed with MPGN at three tertiary care institutions between 2001 and 2010. We investigated the incidence of complement-mediated disease among patients diagnosed with MPGN.
Progressive renal dysfunction was defined as a 50% reduction in the glomerular filtration rate or the need for renal replacement therapy.
Results: Among the 3,294 renal biopsy patients, 77 (2.3%) were diagnosed with MPGN; 31 cases were excluded, of which seven were diagnosed with systemic lupus nephritis, and the others were not followed for a minimum of 12 months after
biopsy. Based on the new classification, complement-mediated MPGN was diagnosed in two patients (4.3%); only one patient developed progressive renal dysfunction. Among the immune complex-mediated MPGN patients, 17 patients
developed progressive renal dysfunction. Serum albumin and creatinine levels at the time of MPGN diagnosis were risk factors of renal deterioration, after adjusting for low C3 levels and nephrotic syndrome.
Conclusion: Complement-mediated glomerulonephritis was present in 4.3% of patients previously diagnosed with MPGN.
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KEYWORD
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Complement C3, Membranous glomerulonephritis, Incidence
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